This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
Aliases： HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; OPTA1; VBCH2
Entrez GeneID： 4041
Swissprot： O75197
WB Predicted band size： 179kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human LRP5 expressed in E. Coli.
