The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
Aliases： APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
Entrez GeneID： 4035
Swissprot： Q07954
WB Predicted band size ： 504kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human LRP1 (AA: 20-155) expressed in E. Coli.
