Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.
Aliases ： DKIR; C3IP1; FLJ27152; KLHL12
Entrez GeneID： 59349
Swissprot ： Q53G59
WB Predicted band size ： 63kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human KLHL12 expressed in E. Coli.
