This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7.
Aliases： IIAE7
Entrez GeneID： 3661
Swissprot： Q14653
WB Predicted band size： 47.2kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human, Mouse, Rat
Immunogen ： Purified recombinant fragment of human IRF3 (AA: 1-150) expressed in HEK293-6e cells supernatant.
