This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases: IPD1; REN64; NY-REN-64
Entrez GeneID: 51135
Swissprot: Q9NWZ3
WB Predicted band sizel : 52kDa
Host/Isotypel: Mouse IgG1
Species Reactivity : Human,Mouse,Rat,,Monkey
Immunogen : Purified recombinant fragment of human IRAK4 expressed in E. Coli.
