Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Aliases ： HD6; JM21; CPBHM; PPP1R90
Entrez GeneID ： 10013
Swissprot ： Q9UBN7
WB Predicted band size ： 131.4kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human HDAC6 (AA: 482-800) expressed in E. Coli.
