This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Aliases： C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
Entrez GeneID： 3002
Swissprot： P10144
WB Predicted band size ： 28kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human GZMB (AA: 21-247) expressed in E. Coli.
