The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes
Aliases： GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1
Entrez GeneID ： 156
Swissprot： P25098
WB Predicted band size ： 80kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human,Mouse,Rat,Monkey
Immunogen： Purified recombinant fragment of human GRK2 expressed in E. Coli.
