The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Aliases： HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
Entrez GeneID： 9568
Swissprot： O75899
WB Predicted band size： 105.8kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human GABBR2 (AA: 319-483) expressed in E. Coli.
