The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Aliases： FGG
Entrez GeneID ： 2266
Swissprot： P02679
WB Predicted band size： 52kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human FGG expressed in E. Coli.
