Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.It is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
Aliases： fibrinogen beta chain
Entrez GeneID： 2244
Swissprot： P02675
WB Predicted band size ： 52kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human,Mouse
Immunogen： Purified recombinant fragment of human FGB (aa30-300) expressed in E. Coli.
