The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
Aliases： PKR; PRKR; EIF2AK1
Entrez GeneID： 5610
Swissprot ： P19525
WB Predicted band size： 62kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human EIF2AK2 (AA: 329-551) expressed in E. Coli.
