This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.
Aliases： ET1; QME; PPET1; ARCND3; HDLCQ7
Entrez GeneID： 1906
Swissprot： P05305
WB Predicted band size： 24.4KDa
Host/Isotype ： Mouse IgG2a
Species Reactivity ： Human, Mouse
Immunogen： Purified recombinant fragment of human EDN1 (AA: 18-212) expressed in E. Coli.
