CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Aliases： TBRS; DNMT3A2; M.HsaIIIA
Entrez GeneID： 1788
Swissprot： Q9Y6K1
WB Predicted band size： 102kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human DNMT3A (AA: 46-180) expressed in E. Coli.
