This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Aliases ： CRKL
Entrez GeneID： 1399
Swissprot： P46109
WB Predicted band size： 39kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human CRKL expressed in E. Coli.
