This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.
Aliases： CHNRA6
Entrez GeneID： 8973
Swissprot： Q15825
WB Predicted band size： 57kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human CHRNA6 (AA: 26-239) expressed in E. Coli.
