The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Aliases: JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1
Entrez GeneID : 182
Swissprot : P78504
WB Predicted band size : 133.8kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human CD339 (AA: extra 47-212) expressed in E. Coli.
