This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.
Aliases： FASLG; APTL; FASL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1
Entrez GeneID： 356
Swissprot： P48023
WB Predicted band size： 31.5kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CD178 (AA: extra 103-281) expressed in E. Coli.
