This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Aliases : SIGLEC5; OBBP2; CD33L2; OB-BP2; SIGLEC-5
Entrez GeneID : 8778
Swissprot : O15389
WB Predicted band size: 60.7kDa
Host/Isotype : Mouse IgG2a
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human CD170 (AA: extra 17-230) expressed in E. Coli.
