The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Aliases： TNFRSF4; OX40; ACT35; IMD16; TXGP1L
Entrez GeneID： 7293
Swissprot ： P43489
WB Predicted band size： 29.3kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CD134 (AA: extra 29-214) expressed in E. Coli.
