This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases： RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
Entrez GeneID ： 8842
Swissprot： O43490
WB Predicted band size： 133kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Synthesized peptide of human CD133.
